I-PromaCare® G-Glucan Ixhasa Ukubuyiselwa Kwamanqanaba Amaninzi Kulusu Olune-UV-Stress

Ubomvu obubonakalayo budla ngokusetyenziswa njengesibonakaliso esikhawulezileyo soxinzelelo lolusu olubangelwa yi-UV. Nangona kunjalo, ukunyamalala kwalo akuthethi ukuba ulusu luphilile ngokupheleleyo. Ukuphazamiseka kwemiqobo, ukwanda kokulahleka kwamanzi e-transepidermal kunye nemiqondiso yomonakalo weeseli ebangelwa yi-UV inokuqhubeka emva kokuba ulusu lubonakala luzolile.

Oku kudala umngeni obanzi wokwenziwa kwesikhumba emva kokukhanya kwelanga. Ukuthomalalisa okwethutyana kunye nokufunxwa kwamanzi kumphezulu kunokuphucula intuthuzelo yolusu kwangoko, kodwa ukuchacha okusebenzayo kufuna inkxaso kwinqanaba lomqobo kunye neleseli.

I-Polysaccharide Echazwe Ngokwesakhiwo Evela Kwi-Fermentation

I-PromaCare® G-Glucan yi-galactoglucan ecocekileyo kakhulu eveliswa ngokubiliswa kweentsholongwane. Ngobunyulu obungaphezulu kwe-90%, inesakhiwo esahlukileyo esicwangciswe ngo-L, esineebhanti ezininzi esiquka iimpawu ze-single-, double- kunye ne-triple-helical.

Olu lwakhiwo lwendawo luxhasa ukusebenzisana nee-receptors ze-lectin zohlobo lwe-C ezifana ne-Dectin-1, zidibanisa isakhiwo se-polysaccharide esichazwe ngokuchanekileyo kunye neempendulo zebhayoloji ezijoliswe kuzo.

Ubungqina Kumanqanaba Amathathu Okubuyiselwa Kolusu

I-PromaCare® G-Glucan ihlolwe ngeemodeli ezongezelelweyo ezijongene nolwakhiwo lomqobo, ukubuyiselwa ngokukhawuleza emva kokukhanya kwelanga kunye nomonakalo we-photomage kwiiseli.

Kwimodeli ye-3D epidermal eyonakeleyo, yonyuse amanqanaba e-filaggrin kunye ne-loricrin ngama-372.24% kunye nama-683.21%, ngokulandelelana. Ezi proteni zizinto ezibalulekileyo zokwahluka kwe-epidermal kunye nokuthembeka komqobo, zixhasa ukubaluleka kwesithako kwiifomyula zokulungisa umqobo.

Ukusebenza kwayo ngokukhawuleza emva kokuphuma kwelanga kuhlolwe kuphando lwabantu kusetyenziswa indlela equlethe i-0.1% yePromaCare® G-Glucan. Kwiiyure ezintathu ukuya kwezintandathu, kwabonwa uphuculo olukhulu ekubomvu kwesikhumba, ukulahleka kwamanzi e-transepidermal kunye nomxholo we-hemoglobin yesikhumba.

Kwinqanaba leeseli, iPromaCare® G-Glucan yehlise ukubonakaliswa kweprotheyini ye-HMGB1 ebangelwa yi-UVB ngama-48.15% kwiiyure ezingama-24 kuxinzelelo lwe-0.0156%. Esi siphumo sibonelela ngobungqina obongezelelweyo bokusetyenziswa kwayo kwiifomyula ezenzelwe ukujongana noxinzelelo lweeseli olunxulumene ne-UV.

Ukuguquguquka kweFomulo kwiZicelo ezininzi

I-PromaCare® G-Glucan inyibilika emanzini ngokwemvelo kwaye ifumaneka ngobunzima beemolekyuli ukusuka kwi-0.1 ukuya kwi-8 yezigidi zeDa. Olu luhlu lunika ii-formulators ukuguquguquka okukhulu xa kusenziwa ii-serum zesikhumba ezibuthathaka, iikhrimu zokulungisa imiqobo, iimveliso emva kokukhanya kwelanga kunye nonyango lokulwa nokwaluphala.

Xa zizonke, ulwakhiwo lwayo oluchaziweyo lweemolekyuli, imveliso ephuma kwi-fermentation kunye nobungqina bokusebenza kakuhle kwamanqanaba amaninzi buxhasa indlela ebanzi ngakumbi yokhathalelo emva kokukhanya kwelanga—ukwandisa uphuhliso lwemveliso ukusuka ekuthomalaliseni okwethutyana ukuya kwinqanaba elibonakalayo, elithintelayo kunye nokubuyiselwa kweeseli.