RJMPDRN®I-REC imele ukuqhubela phambili okubonakalayo kwizithako zokuthambisa ezisekwe kwi-nucleic acid, enikezela ngesalmon ephinda iphinda isetyenziswe iPDRN eyenziwe ngebhayoloji. I-PDRN yesiNtu ngokuyinhloko ikhutshwe kwi-salmon, inkqubo enyanzeliswa ngeendleko eziphezulu, ukuhluka kwe-batch-to-batch, kunye nokucoceka okulinganiselwe. Ngaphaya koko, ukuthembela kwimithombo yendalo kubangela iinkxalabo zozinzo lokusingqongileyo kunye nokunciphisa umlinganiselo wokukhawulelana nemfuno ekhulayo yemarike.
RJMPDRN®I-REC ijongana nale mingeni ngokusebenzisa iintlobo zebhaktiriya ezinobunjineli ukuphindaphinda amaqhekeza ePDRN ekujoliswe kuwo, ivumela ulungelelwaniso olulawulwayo ngelixa igcina umgangatho wokuvelisa kunye nokunciphisa impembelelo yendalo.
Le ndlela yokudibanisa ivumela ukuyila okuchanekileyo kokulandelelana okusebenzayo, okukhokelela kwiimveliso ze-nucleic acid ezilungiselelwe imiphumo ethile ye-bioactive. Ubunzima be-molecular kunye nokwakheka kwesakhiwo seziqhekeza zilawulwa ngokungqongqo, ukuphucula ukufana kunye nokungena kwesikhumba. Njengesithako esingenasilwanyana, i-RJMPDRN®I-REC ihambelana nemigangatho yolawulo lwehlabathi, ukwandisa ukwamkeleka kweemarike kwimimandla ebuthathaka. Inkqubo yokuvelisa ilandela imigangatho engqongqo yomgangatho, isebenzisa iindlela zokuvutshelwa kunye nokuhlanjululwa kwe-scalable ehambisa umgangatho ohambelanayo, ukucoceka okuphezulu, kunye nokubonelela okuthembekileyo-ukujongana neendleko, ukubonelela kunye nemingeni yokusingqongileyo yokukhutshwa okuqhelekileyo.
Physicochemically, RJMPDRN®I-REC imhlophe, i-powder-soluble powder eyenziwe nge-DNA ene-RNA encinci, ephuma kwi-salmon ye-PDRN yokulandelelana, kwaye ibonisa uluhlu lwe-pH lwe-5.0-9.0. Ihlelwa njengesithako se-cosmetic-grade esilungele ukusetyenziswa kwi-emulsions ephezulu, iikhrimu, iipetshi zamehlo, iimaski, kunye nolunye uhlobo lwe-skincare formulations. Izifundo ze-in vitro zibonise ukhuseleko kunye nokusebenza kakuhle kwiimpawu ze-100-200 μg / mL, ezixhasa ukwanda kweeseli kunye nomsebenzi wokuchasana nokuvuvukala ngaphandle kwe-cytotoxicity.
Uphononongo olusebenzayo luqaqambisa ngakumbi i-bioactivity ephezulu ye-RJMPDRN®I-REC. Iphakamisa kakhulu ukufuduka kwe-fibroblast, ukufezekisa izinga lokunyuka kwe-131% kwiiyure ze-41 xa kuthelekiswa nokulawula. Ngokumalunga ne-collagen synthesis, i-RJMPDRN®I-REC ikhuthaza uhlobo lomntu I-collagen ngamaxesha e-1.5 kunye nohlobo lwe-III i-collagen ngamaxesha e-1.1 ngokumalunga nokulawula, ukukhupha i-PDRN eqhelekileyo ye-salmon. Ukongezelela, inqanda kakhulu abalamli abavuthayo njenge-TNF-α kunye ne-IL-6. Xa idibene ne-sodium hyaluronate, , RJMPDRN®I-REC ibonisa iziphumo ze-synergistic, ukwandisa ukufuduka kweeseli, ebonisa amandla anamandla okuqulunqwa kwentsebenziswano kwi-skincare yokuvuselela kunye nokuchasana nokuguga.
Isishwankathelo, i-RJMPDRN®I-REC iquka umtsi wetekhnoloji ukusuka ekutsalweni kwendabuko ukuya kwi-biotechnological synthesis, ibonelela ngokuveliswa kwakhona, ukucoceka okuphezulu, kunye nokugcinwa kweendlela zokwenziwa kwesikhumba esiphezulu. I-bioactivity yayo ebonakalisiweyo, iprofayili yokhuseleko, kunye nokunciphisa ibeka njengesithako esicwangcisiweyo kwiimveliso zokuthambisa ezijolise ekuchaseni ukuguga, ukulungiswa kolusu, kunye nempilo yolusu iyonke, ihambelana ngokupheleleyo nemfuno evelayo yezithako zokuthambisa ezizinzileyo neziqinisekisiweyo ngokwesayensi.
Cofa apha ukuze ufunde ngakumbi malunga nale mveliso.
Ixesha lokuposa: Aug-28-2025