I-RJMPDRN®I-REC imele inkqubela phambili ebalulekileyo kwizithako zobuhle ezisekelwe kwi-nucleic acid, inikezela nge-recombinant salmon PDRN eyenziwe nge-biotechnology. I-PDRN yendabuko ikhutshwa kakhulu kwi-salmon, inkqubo ethintelwa ziindleko eziphezulu, ukuguquguquka kwebhetshi ukuya kwibhetshi, kunye nobunyulu obuncinci. Ngaphezu koko, ukuthembela kwizixhobo zendalo kubangela iinkxalabo zokuzinza kokusingqongileyo kwaye kunciphisa ukuguquguquka ukuhlangabezana neemfuno ezikhulayo zemarike.
I-RJMPDRN®I-REC ijongana nale mingeni ngokusebenzisa iintlobo zebhaktheriya ezilungisiweyo ukuphinda-phinda iziqwenga ze-PDRN ekujoliswe kuzo, ivumela ukwenziwa okulawulwayo ngelixa igcina umgangatho wokuzala kwakhona kwaye inciphisa impembelelo yendalo.
Le ndlela yokudibanisa ivumela uyilo oluchanekileyo lweenkqubo ezisebenzayo, nto leyo ekhokelela kwiimveliso ze-nucleic acid ezenzelwe iziphumo ezithile ezisebenzayo. Ubunzima be-molecular kunye nokuhambelana kwesakhiwo seziqwenga kulawulwa ngokungqongqo, okuphucula ukufana kunye nokungena kwesikhumba. Njengesithako esingenazilwanyana, i-RJMPDRN®I-REC ihambelana nemigangatho yolawulo lwehlabathi, yandisa ukwamkeleka kwemarike kwiindawo ezinobuzaza. Inkqubo yemveliso ilandela imigangatho yomgangatho engqongqo, isebenzisa iindlela zokubilisa ezinokulinganiswa kunye neendlela zokucoca ezibonelela ngomgangatho ohambelanayo, ubunyulu obuphezulu, kunye nobonelelo oluthembekileyo—ukujongana neendleko, uthotho lobonelelo, kunye nemingeni yokusingqongileyo yokukhupha okuqhelekileyo.
Ngokwefiziksi, i-RJMPDRN®I-REC yipowder emhlophe, enyibilikayo emanzini eyenziwe yi-DNA ene-RNA encinci, ethathwe kwi-salmon PDRN sequences, kwaye ibonisa uluhlu lwe-pH oluyi-5.0–9.0. Ihlelwe njengesithako esikumgangatho we-cosmetic esifanelekileyo ukusetyenziswa kwi-emulsions ephezulu, iikhrimu, ii-eye patches, iimaski, kunye nezinye iindlela zokunakekelwa kwesikhumba eziphambili. Izifundo ze-in vitro zibonise ukhuseleko kunye nokusebenza kwayo kumanqanaba e-100–200 μg/mL, ixhasa ukwanda kweeseli kunye nomsebenzi wokulwa nokuvuvukala ngaphandle kwe-cytotoxicity.
Izifundo zokusebenza kakuhle zibonisa ngakumbi ukusebenza okuphezulu kwe-RJMPDRN®I-REC. Iphucula kakhulu ukufuduka kwe-fibroblast, ifikelela kwisantya sokukhula kwe-131% kwiiyure ezingama-41 xa kuthelekiswa nolawulo. Ngokuphathelele ukwenziwa kwe-collagen, i-RJMPDRN®I-REC ikhuthaza i-collagen yohlobo I lomntu ngokuphindwe ka-1.5 kunye ne-collagen yohlobo lwesithathu ngokuphindwe ka-1.1 xa kuthelekiswa nolawulo, iphumelela ngaphezu kwe-PDRN eqhelekileyo ephuma kwi-salmon. Ukongeza, ithintela kakhulu izinto ezibangela ukudumba ezifana ne-TNF-α kunye ne-IL-6. Xa idityaniswe ne-sodium hyaluronate, , RJMPDRN®I-REC ibonisa imiphumo yokusebenzisana, inyusa ukufuduka kweeseli, nto leyo ebonisa amandla amakhulu okusebenzisana ekunyamekeleni ulusu ngendlela yokuvuselela nokuthintela ukwaluphala.
Ngamafutshane, i-RJMPDRN®I-REC ibonakalisa inkqubela phambili kwezobuchwepheshe ukusuka ekutsalweni kwemveli ukuya ekuhlanganisweni kwe-biotechnology, ibonelela ngenye indlela ephinda ivele, icocekile kakhulu, kwaye izinzile yeendlela zokhathalelo lolusu ezikumgangatho ophezulu. Ukusebenza kwayo okubonakalayo, iprofayili yokhuseleko, kunye nokuguquguquka kuyibeka njengesithako esibalulekileyo seemveliso zobuhle ezijolise ekulweni nokwaluphala, ukulungiswa kolusu, kunye nempilo yolusu iyonke, ihambelana ngokupheleleyo nesidingo esiguqukayo sezithako zobuhle ezizinzileyo neziqinisekisiweyo ngokwesayensi.
Cofa apha ukuze ufunde okungakumbi ngale mveliso.
Ixesha lokuthumela: Agasti-28-2025