Ukusuka kwiNdalo ukuya kwiSayensi: Amandla amabini angasemva kwePromaCare PDRN

Ukutyhila isayensi kunye nokuzinza okungasemva kwezithako zethu ze-DNA ezivela kwi-salmon kunye nezityalo

Ukususela oko yavunywa okokuqala e-Itali ngo-2008 ukuze ilungiswe izicubu, i-PDRN (polydeoxyribonucleotide) iye yaguquka yaba sisithako esisemgangathweni ophezulu sokuvuselela ulusu kwiinkalo zonyango kunye nezobuhle, ngenxa yemiphumo yayo emangalisayo yokuvuselela kunye neprofayili yokhuseleko. Namhlanje, isetyenziswa kakhulu kwiimveliso zobuhle, izisombululo zobuhle bezonyango, kunye neendlela zokunakekelwa kolusu zemihla ngemihla.

I-PromaCare PDRNOlu luhlu lusebenzisa amandla e-DNA sodium — isithako sesizukulwana esilandelayo esixhaswa yisayensi kwaye sithembeke kwiikliniki zesikhumba kunye noyilo lwendalo. Ukusuka ekulungisweni kolusu ukuya ekunciphiseni ukudumba, uluhlu lwethu lwe-PDRN luvuselela amandla endalo esikhumba okuphilisa nokuhlaziya. Ngemithombo yolwandle kunye neyezityalo ekhoyo, sinikezela ngeendlela ezisebenzayo, ezikhuselekileyo, neziguquguqukayo ukuze zihambelane neemfuno zanamhlanje zokwenza ulwelo.

I-Salmon-Evela KuyoI-PromaCare PDRN: Ubungqina Bokusebenza Kokuchacha Kolusu

Ithathwe kwisidoda sesalmon,I-PromaCare PDRNIhlanjululwa ngokuhluzwa kwe-ultrafiltration, ukugaya nge-enzyme, kunye ne-chromatography ukufikelela kwi-98% yokufana ne-DNA yomntu. Ivuselela i-adenosine A₂A receptor ukuze iqalise uthotho lwemiqondiso yokulungiswa kweseli. Le ndlela inyusa ukuveliswa kwe-epidermal growth factor (EGF), i-fibroblast growth factor (FGF), kunye ne-vascular endothelial growth factor (VEGF), ezinceda ekulungiseni ulusu olonakeleyo, zikhuthaze ukuvuselelwa kwe-collagen kunye ne-elastin, kwaye zikhuthaze ukwakheka kwe-capillary ukuze kuphuculwe ukuhamba kwezakhamzimba.

Ukongeza ekuphuculeni ulusu kunye nokuqina kwalo,I-PromaCare PDRNikwanciphisa ukudumba kunye nomonakalo we-oxidative obangelwa yimitha ye-UV. Inceda ukulungisa ulusu oluthanda ukuba namaqhakuva nolunobuthathaka, iphucula ukufiphala, kwaye ixhasa ukwakhiwa kwakhona komqobo wolusu ngaphakathi.

Uyilo Olusekelwe Kwizityalo: I-LD-PDRN kunye ne-PO-PDRN Yokusebenza Kakuhle Ngokuqaphela Indalo

Kwiimpawu ezifuna iindlela ezicocekileyo nezizinzileyo ngaphandle kokuphazamisa ukusebenza, i-Uniproma inikezela ngee-PDRN ezimbini ezivela kwizityalo:

I-PromaCare LD-PDRN (iLaminaria Digitata Extract; iSodium DNA)

Esi sithako sithathwe kwi-brown algae (iLaminaria japonica), sibonelela ngeengenelo zesikhumba esinee-multilayer. Sikhuthaza ukuvuselelwa kwesikhumba ngokuphucula umsebenzi we-fibroblast kunye nokukhuthaza ukukhutshwa kwe-EGF, FGF, kunye ne-IGF. Sikwanyusa amanqanaba e-VEGF ukuxhasa ukwakheka kwe-capillary entsha.

Ulwakhiwo lwayo olumdaka lwe-alginate oligosaccharide luzinzisa ii-emulsions, luthintela ukudumba ngokuthintela ukufuduka kwe-leukocyte nge-selectins, kwaye luthintela i-apoptosis ngokulawula umsebenzi we-Bcl-2, i-Bax, kunye ne-caspase-3. Ulwakhiwo lwe-polymer yesithako luvumela amandla amahle okugcina amanzi, ukuthomalalisa, kunye nokwenza ifilimu - ifanelekile ukulungisa ulusu olonakeleyo, oluphelelwe ngamanzi emzimbeni, okanye olucaphukileyo.

I-PromaCare PO-PDRN (iPlatycladus Orientalis Leaf Extract; iSodium DNA)

Le PDRN esekelwe kwizityalo isuka kwiPlatycladus Orientalis kwaye inika iziphumo zokulwa neentsholongwane, ukudumba, kunye nokufumisa. Iioyile eziguquguqukayo kunye neeflavonoids kwisicatshulwa ziphazamisa ii-membrane zebhaktiriya kwaye zithintele ukwenziwa kwe-nucleic acid, ngelixa ii-anti-inflammatory agents zithintela indlela ye-NF-κB ukunciphisa ubomvu kunye nokurhawuzelelwa.

Iipolysaccharides zayo ezifumisayo zenza umaleko obopha amanzi eluswini, zivuselela ukwenziwa kwezinto ezifumisayo kwendalo kwaye ziqinise umqobo. Ikwaxhasa ukuveliswa kwe-collagen kwaye iqinisa ii-pores - ezinegalelo ekulungeni okuthambileyo nokuthambileyo.

Zombini ii-PDRN zezityalo zikhutshwa ngqo kwiiseli zezityalo kusetyenziswa inkqubo engqongqo yokucoca, enika uzinzo oluphezulu, ukhuseleko, kunye nesisombululo esicocekileyo sokhathalelo lolusu olusebenza kakuhle.

Iqhutywa yiSayensi, Ijolise kwikamva

Iziphumo ze-in vitro zibonisa ukuba i-0.01% ye-PDRN yonyusa ukwanda kwe-fibroblast kumanqanaba afana ne-25 ng/mL ye-EGF. Ngaphezu koko, i-0.08% ye-PDRN yonyusa kakhulu ukwenziwa kwe-collagen, ingakumbi xa isetyenzwa ukuya kubunzima obuphantsi beemolekyuli.

Nokuba ulungiselela ukulungiswa kwemiqobo, ukhathalelo lokwaluphala, okanye ukudumba, i-Uniproma'sI-PromaCare PDRNuluhlu lubonelela ngeendlela ezinamandla ezixhaswa ziindlela ezicacileyo kunye nokufunyanwa okuguquguqukayo.

I-salmon okanye i-plant — ukhetho lolwakho. Iziphumo ziyinyani.