Uyilo lwezinto eziluhlaza ezintsha

Ukuzibandakanya kweemolekyuli

--ikhemistri eluhlaza engaphandle kokuqhawuka kwebhondi kunye nokudibana kwakhona

Umgaqo oyintloko wokuzihlanganisa kweemolekyuli:

1. Izinto ezifana nezi zitsala izinto ezifanayo ukuze ziqokelelane kwaye zilungelelaniswe, kunye nezinto ezineempawu ezihambelanayo ukuze zitsalane.

2. Amandla aphantsi—ukuhamba kwezinto kunye nokuziphatha kweemolekyuli kuya kufikelela kwimeko ezinzileyo. Yindlela yokuba amaqela eemolekyuli ahlelwe abe zizakhiwo eziphambili.

Uyilo lwe-molecular self-building, ulwakhiwo lwe-CP phakathi kwee-molecules lunokuphucula kakhulu umsebenzi webhayoloji:

1. Imolekyuli nganye inesakhiwo sayo esahlukileyo kunye neempawu zayo zokusebenza, kwaye kunzima ukufikelela kwintsebenziswano kunye nonyango oluchanekileyo olusekelwe ekuxutyweni ngokukhululekileyo kwinqanaba lokwenziwa.

2. Kusekho iimolekyuli ezininzi ezinomsebenzi obalaseleyo webhayoloji eziye zanciphisa kakhulu ukufunxwa kwazo kunye nokusetyenziswa kwazo ngenxa yeempawu zazo ezimbi.

3. Izinto ezisebenzayo zonyango lwesintu lwaseTshayina zibaluleke kakhulu "ngookumkani, abaphathiswa kunye nabancedisi", endaweni yokuba zibe yingxokolo, kokukhona zingcono.

Imodeli yenkqubo yokuhlaziya uhlengahlengiso lwesakhiwo seSupramolecular kunye nokuphucula ukusebenza:

1. Ukuhlolwa kwe-high-throughput okuncediswa yikhompyutha ukuze kuhlolwe ngokukhawuleza izinto ezifanelekileyo ezivela kwiCambridge Crystal Data Center.

2. Sebenzisa ithiyori yokusebenza koxinano ukuze ufunde isakhiwo se-supramolecular kunye neempawu zokuhlanganisa ezimiselwe ngamandla aphakathi kwe-molecular, kwaye umisele ukuba loluphi uhlobo lwe-supramolecular oluyindlela yokwakheka.

3. Ngokuhlalutya iimeko zokusabela kunye nobunzima, ulwakhiwo lwe-supramolecular lwenziwe ngcono.

4. Ukubalwa kweempawu ezahlukeneyo ze-supramolecules, kuquka iimpawu zombane, ezibonakalayo kunye ne-thermodynamic.

5. Ukubalwa kweempawu ze-spectral ezifana ne-molecule spectrum kunye ne-energy spectrum.

6. Ngokusebenzisa itekhnoloji yokubeka iimolekyuli, iindawo zokunxibelelana phakathi kwezinto eziluhlaza ze-supramolecular kunye neeproteni ezijoliswe kuzo ziqikelelwa, kwaye indlela yokusebenzisana phakathi kweemolekyuli ichazwe nzulu.

Itekhnoloji yetyuwa ye-Supramolecular eutectic/Ionic

Iimpawu zobugcisa: eyokuqala kushishino, ukuhlola ezona nxalenye zibalaseleyo ze-CP zezakhi ezisebenzayo zokuqinisa i-eutectic

Iingenelo: ukunciphisa ukurhawuzelela, ukuphucula ukunyibilika, ukuphucula ukusebenza, ukukhuthaza ukungena kwamanzi, ukuphucula uzinzo

Imizekelo yezithako: i-salicylic acid, i-uric acid, i-ferulic acid, i-glycyrrhizic acid, i-adenosine, i-niacinamide, i-4MSK

Izithako ezisebenzayo zendalo ezithathwe kwikhathalogu yezinto zokuhlobisa, emva kovavanyo lokuqinisekisa olufana nokulinganisa iikhemikhali ze-quantum, ukuhlolwa okuphezulu, ukulungiswa kweGaussian, iKingDraw, iMestReNova, iFTIR, kunye ne-NMR, iimveliso ezifunyenweyo zinesakhiwo sekristale esibalaseleyo esinemilinganiselo emithathu, uzinzo oluhle, ubunyulu obuphezulu, ukungcola okuncinci. Ingasombulula ngempumelelo amanqaku entlungu yokusetyenziswa kwezithako ezisebenzayo ekutyeni, kumayeza nakwizithambiso, kwaye iphucule ukufumaneka kwezinto eziphilayo kunye nokhuseleko lwezithako ezisebenzayo.

Itekhnoloji yokukhupha umsebenzi we-Supramolecular

iimpawu zobugcisa: Eyokuqala kushishino, indibaniselwano yetekhnoloji yokushicilela iimolekyuli kunye nezinyibilikisi zendalo ze-supramolecular, ukukhupha ngempumelelo izithako ezisebenzayo zezityalo

Iingenelo: Ukukhupha okujoliswe kuko, ukusebenza kakuhle kokukhupha kuyanda ngokuphindwe kahlanu xa kuthelekiswa nokukhupha utywala, kwaye ukukhupha amanzi kuyanda ngokuphindwe ka-20; akukho kuhlukaniswa, ukunciphisa iindleko, Izithako ezikhuthaza ukungena Imizekelo: i-olive (oleuropein, i-hydroxytyrosol), i-rhodiola, i-medical Phyloporus, i-white water lily, i-micrococcus

I-Natural deep eutectic solvent (NaDES): Yafunyanwa okokuqala zizazinzulu kuhlalutyo lwe-plant metabolomics. Ngexesha elithile lophuhliso lwezityalo (ukuhluma, ukugcinwa kwe-cryopreservation), iiseli ziya kuzenzela ngokuzenzekelayo ulwelo oluqinileyo oluzimeleyo emanzini kunye ne-lipids, olufana nomxube we-eutectics.

Ngokusekelwe kubuchwepheshe bokwahlukanisa oluhlaza banamhlanje, iteknoloji ye-membrane edibeneyo, encediswa yiteknoloji yokuphucula i-ultrasonic / microwave ukufezekisa ubushushu obuphantsi, ukujoliswa, ubuchule obuphezulu, umgangatho ophezulu kunye nokukhupha okuluhlaza kwezinto ezisebenzayo. Ngokusebenzisa i-solvent yendalo ye-supramolecular njenge-solvent yokukhupha esebenzayo, isombulula iingxaki ezininzi ezifana nokusebenza okuphantsi, iindleko eziphezulu kunye nobunzima ekubuyiselweni kolwelo olulahliweyo lwe-phytochemical extraction yendabuko. I-solvents ye-supramolecular ekhutshiweyo ikhethwe ngenxa yokusebenza kwayo. I-solvent ye-supramolecular ekhethiweyo inokusebenza okuzinzileyo kunye nokunyibilika okuphuculweyo kwezithako ezisebenzayo, kunye nokusebenza kakuhle kokukhupha kunokwandiswa ngamaxesha angama-20.

Itekhnoloji yokungena kwe-Supramolecular synergistic

Iimpawu zobugcisa: Eyokuqala kushishino, ngokusebenzisa isinyibilikisi se-supramolecular, ikhuthaza ngokudibeneyo ukungena kwee-macromolecules/ezinyibilikayo emanzini/ezinzima ukufunxa izithako.

Iingenelo zobugcisa: ukuzinza okuphuculweyo, ukuphucula ukungena okungonakalisiyo nokusebenzayo, isiphumo sokusebenzisana, ukutyebisa kwicala kwi-dermis, kunye nokufumaneka kwezinto eziphilayo kwanda ngama-5-7 amaxesha. Imizekelo yezithako: i-collagen, i-Bosein, i-blue copper peptide, i-hexapeptide, i-compound peptide, i-β-glucan.

Ekubeni ubunzima bemolekyuli yepeptide busebukhulu xa buthelekiswa nezinye izithako ezisebenzayo, ukungena kwesikhumba kuphantsi. Kufuneka iindlela ezithile zokuphucula ukungena kwepeptide ukuze kuphuculwe isiphumo sokufunxwa kokungena kwepeptide, ukuze kufezekiswe uxinaniso oluphantsi kunye nokusebenza okuphezulu, kwaye kufezekiswe ukusebenza ngcono kokulwa nokwaluphala.

Ngenxa yokuba i-JUNAS Time Particle products ingena kakuhle kwishishini, i-hydrophilicity ephezulu kunye ne-bioavailability ephantsi ye-macromolecules zemveli, ukwenziwa kwe-JUNAS Time Particle products nge-quantum chemistry encediswa yi-quantum chemistry, inokufikelela ngqo kwi-epidermis kunye ne-dermis yesikhumba ngokusebenzisa i-trans-cellular, intercellular kunye ne-follicular sweat duct channels. Ngaphandle kokonakalisa isakhiwo sesikhumba. I-bioavailability yemveliso inyuswa ngama-5 amaxesha, kubandakanya ngaphezulu kwe-45% kwi-dermis, ngaphandle kokonakalisa isakhiwo sesikhumba. Isiphumo sokungena kunye nexesha lokuhlala kuye kwaphunyezwa uphuculo olukhulu. Olu lolona hlobo lokuqala kwishishini.

Itekhnoloji ye-Supramolecular biocatalysis

I-catalysis ekhokelwa yi-Bioenzyme: izinyibilikisi ze-supramolecular zisetyenziswa njengeziseko zokuphucula umsebenzi we-enzyme, ukuphucula ukhetho lwe-chiral, kunye nokufezekisa ubunyulu obuphezulu

Ubunjineli bokuvutshelwa okuluhlaza kwefennel: khetha izityalo ezizizo, uphucule umxholo wezithako ezisebenzayo, ifomula engenamanzi, uphucule ukusebenza kakuhle kwayo yonke

Itekhnoloji yokubilisa i-micellar eguqukayo: ukuhluza iintlobo zeempawu, ukubilisa ioyile yemifuno, iziphumo ezingaphezulu, ukuphucula indlela ulusu oluvakalelwa ngayo kunye nokuphucula ukufunxwa kwayo

Ngokusekelwe kwiteknoloji ye-recombinant gene, iteknoloji ye-one-step gene cloning kunye neteknoloji ye-high-density bioenzyme catalytic, iibhaktheriya ezenziwe nge-genetic zisetyenziswa njengabathwali be-catalytic ukuphumeza ukuveliswa okukhulu kwezinto ezisebenzayo:

Phantsi kwenkqubo ye-supramolecular solvent, i-enzyme ibonisa umsebenzi ophezulu, ukukhetha kunye nozinzo, ukusetyenziswa okuphezulu kwezinto ezikrwada ze-substrate, ungcoliseko oluncinci kwinkqubo yemveliso, iimeko zokuphendula ezithambileyo, ukusebenza okuphezulu kokhuseleko kunye nokusebenza kwemveliso.

Itekhnoloji yokubilisa i-micelle eguqukayo:

Iioyile zendalo ezikhethiweyo ezineempawu zaseTshayina i-lP zenzelwe ngokuzenzekelayo ukuvelisa ii-surfactants phantsi kwesenzo sebhaktheriya eyenziwe ngokwezakhi zofuzo. I-lt ihlanganiswe njengomthwali we-anti-micellar bundle ukuze kufezekiswe ukugoqwa kwe-anti-micellar bundle kwezithako ezisebenzayo ezinyibilikayo emanzini ukuze kufezekiswe iimeko zokusetyenziswa ezityebileyo, amava okugqibela esikhumba, kunye nokusebenza okumangalisayo, amava, kunye nokusebenza okubalulekileyo.

Itekhnoloji ye-Supramolecular microencapsulation

Iimpawu zobugcisa: ukufakwa kwe-liposome, ukukhululwa okujoliswe kuko kweeseli zesikhumba, ukukhululwa okujoliswe kuko kwee-follicles zeenwele, kunye nokukhululwa okusabelayo kwezinto ezibangela ukudumba.

Iingenelo: Ukwenziwa kwe-nano, ukuhanjiswa ngokuchanekileyo, ukukhululwa okuhlala ixesha elide, ukunciphisa ukurhawuzelelwa, ukuphucula uzinzo, kunye nokukhuthaza ukungena kwamanzi

Imizekelo yezithako: i-astaxanthin, i-glabridin, i-vitamin A, i-blue copper peptide, i-biotin, i-ceramide, i-plant essential oil

Itekhnoloji ye-Supramolecular microencapsulation isekelwe kwi-liposome, i-fat emulsion, itekhnoloji ye-ionic liquid stabilization, itekhnoloji yokukhulula iiseli zesikhumba, itekhnoloji yokukhulula iinwele, kunye netekhnoloji yokukhulula izinto ezibangela ukudumba. Ngokwenza imijelo yokuthutha eyenziweyo, imveliso inokuhambisa izithako ezisebenzayo ngokuchanekileyo. Inesantya esihle sokufunxa i-transdermal, ihlala ixesha elide kwaye izinzile kwindawo ekujoliswe kuyo ulusu. Ikwanazo neendleko eziphantsi kunye nokusetyenziswa okuphezulu kwicandelo lezinto zokuthambisa, ukutya okusebenzayo kunye namayeza.

Itekhnoloji yokuzihlanganisa ngokwezikhundla zePeptide

Iimpawu zobugcisa: ulawulo lokuqala olujoliswe kulo shishino lwesakhiwo samanqanaba amaninzi see-amino acid chain kunye nee-polypeptides, ii-peptides ezimfutshane ezizihlanganise ngokwazo, ii-polypeptides ze-supramolecular

Isikhokelo sobuchwephesha: Ukuphucula ukuguquguquka kwamanzi, ukomeleza uzinzo kunye nokumelana nobushushu, ukunciphisa ubuthi kunye noxinzelelo lomzimba, ukukhuthaza ukufunxwa, kunye nokusebenzisana

Imizekelo yezithako: i-supramolecular carnosine, i-yeast protein peptide

Ukuzihlanganisa kweeproteni kunye neepeptide akupheleli nje ekufumanekeni kwiindawo ezininzi zobomi, kodwa kukwayinto ebalaseleyo ephilayo emzimbeni womntu, kwaye yenye yeendlela ezisebenzayo zokwenza izinto ze-nano-biological. Inkqubo yokuzihlanganisa ye-peptide yinkqubo yokuhlanganisa ngokwe-hierarchical, kwaye "isakhiwo se-zipper se-polar amino acid" luhlobo olutsha lwesakhiwo se-super-secondary, esilungele ukuhlanganiswa kwe-hierarchical yee-peptides ukwenza ii-aggregates ezicwangcisiweyo.

Ulawulo oluchanekileyo lobukhulu beepeptides ezimfutshane lunokufezekiswa ngokutshintsha i-hydrophobicity kunye ne-side chain branching yee-residues ze-hydrophobic.

Ngokusekelwe kwisiseko sedatha seShinehigh Innovation seProteinDataBank (PDB), dibanisa nokujongwa okucwangcisiweyo kovavanyo, i-molecular dynamics kunye nokubalwa kwe-quantum chemistry ukuhlalutya ulwakhiwo lwee-peptide molecules, uze uzifanise nee-high-throughput self-assembly molecules. Ukuguqulwa kohlobo, inani kunye nendawo ehambelanayo yee-amino acids phakathi kwee-peptide molecules ukutshintsha isakhiwo sazo esithile sokusonga, ngaloo ndlela kuphucula amandla e-molecule okuzihlanganisa. Ukuqonda ukulawulwa okujoliswe kuko kwee-peptides. I-peptide ezihlangeneyo inomlinganiselo ophezulu kunye nokulingana, okuphucula kakhulu uzinzo lwe-peptide, amandla e-transdermal kunye nokufumaneka kwe-bioavailability.