Uyilo lwemathiriyeli ekrwada

Ukuzihlanganisa kweemolekyuli

--umda wekhemistri eluhlaza ngaphandle kokuqhawula ibhondi kunye nokudibanisa kwakhona

Umgaqo ongundoqo wokuzihlanganisa ngokwazo iimolekyuli:

1. Njengokutsala umdla - ukuqhuba izinto ezifanayo ukuqokelela kunye nokucwangcisa enye kwenye, kunye nezinto ezineempawu ezihambelanayo ukutsala enye kwenye.

2. Awona mandla asezantsi-intshukumo yezinto kunye nokuziphatha kwemolekyuli kuya kuthambekela kwezona meko zizinzile. Yindlela yokuba amaqela eemolekyuli alungelelaniswe abe ngamacandelo ahambele phambili.

I-molecular self-assembly-designability, isakhiwo se-CP phakathi kweemolekyuli sinokuphucula kakhulu umsebenzi webhayoloji:

1. I-molecule nganye inesakhiwo sayo esiyingqayizivele kunye neempawu ezisebenzayo, kwaye kunzima ukufezekisa i-synergy kunye nonyango oluchanekileyo olusekelwe ekuxubeni kwamahhala kwinqanaba lokuqulunqa.

2. Kusekho iimolekyuli ezininzi ezinomsebenzi ogqwesileyo webhayoloji ezithintele kakhulu ukufunxa kunye nokusetyenziswa kwazo ngenxa yeempawu zazo ezimbi.

3. Izinto ezisebenzayo zamayeza emveli aseTshayina zibaluleke kakhulu malunga "nenkosi, abaphathiswa kunye nabancedisi", kunokuba i-hodgepodge ibe ngcono ngakumbi.

Ukuguqulwa kwesakhiwo se-Supramolecular kunye nemodeli yenkqubo yohlalutyo lokuphucula:

1. I-Computer-aid-high-throughput screening yokukhangela ngokukhawuleza i-precursors efanelekileyo evela kwi-Cambridge Crystal Data Centre.

2. Sebenzisa ithiyori esebenzayo yoxinaniso ukufunda i-supramolecular structure kunye ne-assembly properties ezigqitywe yi-intermolecular forces, kwaye ubone ukuba yeyiphi na i-supramolecular type is the formation trend.

3. Ngokuhlalutya iimeko zokuphendula kunye nobunzima, isakhiwo se-supramolecular salungiswa.

4. Ukubalwa kweepropati ezahlukeneyo ze-supramolecules, kubandakanywa umbane, i-optical kunye ne-thermodynamic properties.

5. Ukubalwa kweepropati ze-spectral ezifana ne-molecular spectrum kunye ne-energy spectrum.

I-6.Nge-teknoloji ye-molecular docking, iisayithi zokusebenzisana phakathi kwezinto eziluhlaza ze-supramolecular kunye neeprotheni ezijoliswe kuzo ziqikelelwe, kwaye indlela yokusebenzisana phakathi kweeamolekyu ichazwe ngokunzulu.

Itekhnoloji yetyuwa ye-Supramolecular eutectic/Ionic

Iimpawu zobuchwephesha: eyokuqala yoshishino, ihlola ezona nxalenye zeCP zamacandelo asebenzayo okomeleza i-eutectic

Izinto eziluncedo: ukunciphisa ukucaphuka, ukuphucula ukunyibilika, ukuphucula ukusebenza, ukukhuthaza ukunyanzeliswa, ukuphucula ukuzinza

Imizekelo yezithako: isalicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Izithako ezisebenzayo zendalo ezithatyathwe kwikhathalogu yezinto ezithambisayo zokuthambisa, emva kovavanyo lokuqinisekisa olufana nokulinganisa imichiza ye-quantum, ukuhlolwa okuphezulu, ukwenziwa ngcono kwe-Gaussian, i-KingDraw, i-MestReNova, i-FTIR, kunye ne-NMR, iimveliso ezifunyenweyo zinemigangatho egqwesileyo yekristale enamacala amathathu, uzinzo oluhle, ukucoceka okuphezulu, ukungcola okuncinci. Iyakwazi ukusombulula ngempumelelo iintlungu zesicelo sezithako ezisebenzayo ekutya, amayeza kunye nezithambiso, kunye nokuphucula i-bioavailability kunye nokhuseleko lwezithako ezisebenzayo.

Itekhnoloji yokukhupha umsebenzi we-Supramolecular

Iimpawu zobuchwephesha: Ishishini lokuqala, indibaniselwano yetekhnoloji yoshicilelo lwemolekyuli kunye nezinyibilikisi zendalo ze-supramolecular, ukutsalwa okusebenzayo kwezityalo ezisebenzayo.

Iingenelo: Ukutsalwa okujoliswe kuko, ukusebenza kakuhle kokukhutshwa kwandiswe ngamaxesha angama-5 xa kuthelekiswa nokutsalwa kotywala, kwaye ukutsalwa kwamanzi kwandiswe ngamaxesha angama-20; akukho kwahlulwa, kucuthwa iindleko, izithako ezikhuthaza ukungena Imizekelo: umnquma (oleuropein, hydroxytyrosol), irhodiola, iPhyloporus yamayeza, inyibiba yamanzi amhlophe, imicrococcus

I-solvent yendalo enzulu ye-eutectic (NaDES): Yafunyanwa okokuqala zizazinzulu kuhlalutyo lwe-metabolomics yezityalo. Ngexesha elithile lophuhliso lwezityalo (ukuhluma, i-cryopreservation), iiseli ziza ngokuzenzekelayo zenze ulwelo olubonakalayo oluzimeleyo oluzimeleyo kumanzi kunye ne-lipids, olufana nomxube we-eutectics.

Ngokusekelwe kwitekhnoloji yanamhlanje yokwahlula okuluhlaza, itekhnoloji ye-membrane edibeneyo, encediswa yi-ultrasonic / iteknoloji yokuphucula i-microwave ukufezekisa ukushisa okuphantsi, okujoliswe kuyo, i-ciency ephezulu, umgangatho ophezulu kunye nokutsalwa okuluhlaza kwezinto ezisebenzayo.Nge-solvent yendalo ye-supramolecular njenge-efficacy extraction solvent, ixazulula iingxaki ezininzi ezifana nokusebenza okuphantsi, iindleko eziphezulu kunye nobunzima bokufumana inkunkuma yokubuyisela ulwelo lwe-phytochemical ekhethiweyo. I-solvent ye-supramolecular ekhethiweyo inomsebenzi ozinzile kunye ne-solubility ephuculweyo yezithako ezisebenzayo, kunye nokusebenza kakuhle kwe-extraction kunokunyuswa ngamaxesha angama-20.

Itekhnoloji yokungena kwi-Supramolecular synergistic

Iimpawu zobugcisa: Ishishini lokuqala, ngokusebenzisa i-solvent ye-supramolecular synergistically ikhuthaza ukungena kwe-macromolecules / i-soluble yamanzi / kunzima ukufunxa izithako.

Iingenelo zobuchwephesha: ukuphuculwa kozinzo, ukungonakalisi kunye nokusebenza kakuhle kokungena, i-synergistic effect, i-directional enrichment in the dermis, kunye ne-bioavailability yanda ngamaxesha e-5-7 Izithako imizekelo: i-collagen, i-Bosein, i-peptide yethusi eluhlaza okwesibhakabhaka, i-hexapeptide, i-peptide edibeneyo, i-β-glucan.

Kuba ubunzima bemolekyuli yepeptide isebukhulu kakhulu xa kuthelekiswa nezinye izithako ezisebenzayo, ukungena kwesikhumba kuphantsi. Ezinye iindlela zokuphucula ukungena ziyafuneka ukuze kuphuculwe impembelelo yokungena ephuculweyo yepeptide, ukuze kuzuzwe ukugxininiswa okuphantsi kunye nokusebenza okuphezulu, kunye nokufezekisa ukusebenza kakuhle kokuchasana nokuguga.

Ukuphendula kwindawo ebuhlungu yoshishino lokungenwa kakubi, i-hydrophilicity ephezulu kunye ne-bioavailability ephantsi ye-macromolecules yendabuko, i-JUNAS Time Particle iimveliso synthesis nge-quantum chemistry incediswa, inokufikelela ngokuthe ngqo kwi-epidermis kunye ne-dermis yesikhumba ngokusebenzisa i-trans-cellular, i-intercellular kunye ne-follicular sweat ductchannels. Ngaphandle kokonakalisa isakhiwo solusu.I-bioavailability yemveliso inyuswe ngamaxesha e-5, kubandakanywa ngaphezu kwe-45% kwi-dermis, ngaphandle kokonakalisa isakhiwo sesikhumba.Impembelelo yokungena kunye nexesha lokuhlala liye laphunyezwa uphuculo olubalulekileyo.Le yinto yokuqala yohlobo lwayo kwishishini.

Itekhnoloji ye-supramolecular biocatalysis

I-catalysis ekhokelwa yi-Bioenzyme: izinyibilikisi ze-supramolecular zisetyenziselwa ukunyusa umsebenzi we-enzyme, ukuphucula ukhetho lwe-chiral, kunye nokufezekisa ubunyulu obuphezulu.

Ubunjineli befennel eluhlaza fermentation: khetha izityalo ezinophawu, uphucule umxholo wezithako ezisebenzayo, i-anhydrous formula, ukuphucula ukusebenza kakuhle.

Ukuguqula itekhnoloji ye-micellar fermentation: ukuhlolwa kweempawu, ukubilisa ioyile yemifuno, iziphumo ezingaphezulu, ukuphucula ukuziva kolusu kunye nokuphucula ukufunxa.

Ngokusekwe kwitekhnoloji yemfuza ephinda iphinde yadibana, itekhnoloji ye-cloning yenqanaba elinye kunye netekhnoloji yoxinaniso oluphezulu lwe-bioenzyme catalytic, iibhaktheriya ezenziwe ngofuzo zisetyenziswa njengabathwali be-catalytic ukuqonda imveliso enkulu yezinto ezisebenzayo:

Ngaphantsi kwenkqubo ye-solvent ye-supramolecular, i-enzyme ibonisa umsebenzi ophezulu, ukukhetha kunye nokuzinza, ukusetyenziswa okuphezulu kwezinto eziluhlaza ze-substrate, ukungcola okuncinci kwinkqubo yokuvelisa, iimeko zokusabela kancinci, ukusebenza okuphezulu kokhuseleko kunye nokusebenza kwemveliso.

Buyisela umva itekhnoloji ye-micelle fermentation:

i-oyile yendalo ekhethiweyo eneempawu zaseTshayina i-lP yenzelwe ngokuzenzekelayo ukuvelisa i-surfactants phantsi kwesenzo se-bacterial engineered genetically.lt ihlanganiswe njengomphathi we-anti-micellar bundle ukuqonda i-anti-micellar bundle wrapping of water-soluble active ingredients ukuphumeza iimeko zesicelo esityebileyo, amava okugqibela esikhumba, kunye namava, ukusebenza kakuhle kunye nokubaluleka okuphawulekayo.

Itekhnoloji ye-Supramolecular microencapsulation

Iimpawu zobuchwephesha: i-liposome encapsulation, ukukhutshwa okujoliswe kuyo kweeseli zedermal, ukukhululwa okujoliswe kuyo kweefollicle zeenwele, kunye nokukhululwa okuphendulayo kwezinto ezivuthayo.

Izinto eziluncedo: I-Nanoization, ukuhanjiswa okuchanekileyo, ukukhutshwa kwexesha elide, ukunciphisa ukucaphuka, ukuphucula ukuzinza, kunye nokukhuthaza ukufikeleleka.

Imizekelo yezithako: i-astaxanthin, i-glabridin, ivithamin A, i-peptide yobhedu eluhlaza, i-biotin, i-ceramide, i-oyile ebalulekileyo yesityalo

I-teknoloji ye-supramolecular microencapsulation isekelwe kwi-liposome, i-emulsion ye-fat, i-ionic liquid stabilization technology, i-dermal cell ejoliswe kwi-teknoloji yokukhululwa, i-follicle ye-hair follicle ekujoliswe kuyo iteknoloji yokukhululwa, kunye ne-inflammation factor responsive release release.Ngokudala iziteshi zothutho ezenziweyo, imveliso inokuhambisa izithako ezisebenzayo ngokuchanekileyo. Inezinga eliphezulu lokufunxa kwe-transdermal, ixesha lokuhlala ixesha elide kunye nozinzo oluhle kwindawo ekujoliswe kuyo kulusu. Ikwanayo neendleko eziphantsi kunye nezicelo eziphezulu zokusebenza kwintsimi yezimonyo, ukutya okusebenzayo kunye namayeza.

Itekhnoloji ye-Peptide yokuzihlanganisa ngokwamanqanaba

Iimpawu zobuchwephesha: Ishishini lokuqala, ummiselo ojoliswe kuwo wesakhiwo se-amino acid kunye neepolypeptides, iipeptide ezimfutshane ezizihlanganisileyo, iipolypeptides ze-supramolecular.

Umkhombandlela wobuchwephesha: Phucula i-amphiphilicity, yongeza uzinzo kunye nokumelana nobushushu, ukunciphisa ubuthi kunye noxinzelelo lomzimba, ukukhuthaza ukufunxa, kunye nokudibanisa.

Imizekelo yezithako: supramolecular carnosine, yeast protein peptide

Ukuzihlanganisa ngokwakho kweeprotheyini kunye neepeptide azikho kuyo yonke indawo kwiinkqubo zobomi, kodwa kwakhona yinto egqwesileyo engapheliyo kumzimba womntu, kunye nenye yeendlela ezisebenzayo zokwenza izinto ze-nano-biological. Inkqubo yokudibanisa i-peptide yinkqubo yendibano ye-hierarchical, kwaye "i-polar amino acid zipper structure" luhlobo olutsha lwesakhiwo se-super-secondary, esinceda kwindibano ye-hierarchical yeepeptides ukwenza ii-aggregates eziyalelweyo.

Ukulawulwa kwesikhokelo sobungakanani beepeptide ezimfutshane kunokufezekiswa ngokuguqula i-hydrophobicity kunye ne-side chain branching yeentsalela ze-hydrophobic.

Ngokusekwe kwisiseko sedatha yeProteinDataBank (PDB) eyodwa ye-Shinehigh Innovation, idibanisa kunye nokuqwalaselwa kovavanyo olucwangcisiweyo, i-molecular dynamics kunye nezibalo zemichiza ye-quantum ukuhlalutya isakhiwo seemolekyuli ze-peptide, kwaye emva koko zitshatise kunye ne-high-throughput self-assembly molekyuli. ngaloo ndlela iphucula isakhono semolekyuli ukuzihlanganisa.Ukuqonda ummiselo ekujoliswe kuwo weepeptides. I-peptide ezihlangeneyo ine-amphiphilicity egqwesileyo kunye ne-symmetry, ephucula kakhulu ukuzinza kwe-peptide, isakhono se-transdermal kunye ne-bioavailability.