I-INCI efanayo, Ibali loNikezelo olwahlukileyo: Ukuqonda i-Recombinant PDRN

I-PDRN ifumana ingqalelo engakumbi kukhathalelo lolusu, kodwa igama le-INCI lodwa alibonisi indlela efumaneka okanye eveliswa ngayo isithako.

Ngaphakathi kwipotifoliyo ye-PDRN ye-Uniproma, zombini i-PDRN efumaneka kwi-salmon kunye ne-recombinant zichongwa njenge-Sodium DNA. Nangona zinophawu olufanayo lwe-INCI, ezi ndlela zimbini zahlukile kakhulu kwindlela yemveliso, ulawulo lomgangatho kunye nokukhula kobonelelo.

I-PDRN evela kwi-salmon inika indawo yokuqala ebalulekileyo yesayensi ngenxa yembali yayo esele imiselwe kunyango lokuvuselela, usetyenziso lobuhle kunye nokhathalelo lolusu. Ngokusebenzisa olu lwazi, i-Uniproma yenze ulandelelwano olubanzi kunye nothelekiso lweemveliso ze-PDRN kunye ne-PN zorhwebo, ikhetha iziqwenga zejini ezingama-99 ezifanelekileyo zophuhliso oluqhubekayo lwe-recombinant.

Ngokungafaniyo nokukhupha okuqhelekileyo kwizicubu zebhayoloji, i-PDRN ephinda i-recombinant ilandela indlela yokuvelisa elawulwayo:

Ukukhethwa kolandelelwano lweethagethi → ukwakhiwa kweplasmid → ukubiliswa kweentsholongwane → ukubanjwa kwemveliso ekujoliswe kuyo → ukucocwa komsinga

Emva kokubiliswa, iinkqubo zokucoca ezisezantsi zenzelwe ukususa ii-metabolites zokubiliswa, iiproteni ze-host-cell kunye ne-DNA ye-host-cell, kunye ne-ion-exchange chromatography ebonelela ngenyathelo elongezelelweyo lokucoca. Le nkqubo ilawulwayo ixhasa ubunyulu, ukuhambelana kwebhetshi kunye nokulandeleka kobuchwephesha.

Ukuveliswa okusekelwe ekuvuthweni kunciphisa ukuxhomekeka kwizixhobo zebhayoloji zonyaka kwaye kubonelela ngendlela enokwandiswa ukusuka kubungakanani bophuhliso ukuya kwimveliso yorhwebo.

Ukusebenza kakuhle nako kuhlolwe ngaphakathi emzimbeni. Emva kweentsuku ezingama-28 zokusetyenziswa kwi-0.1%, i-recombinant PDRN ibonise oku kulandelayo:

·Ukunciphisa kwe-TEWL nge-17.37%

·Ukuncipha kwe-erythema nge-12.40%

·Ukuphuculwa kokuqina kolusu nge-30.11%

·Ukuncipha kwenani lemibimbi nge-46.67%

Ezi ziphumo zixhasa amandla ayo okulungisa imiqobo, ukuthomalalisa, ukuqinisa kunye nokulungisa imibimbi.

Kubaqulunqi kunye neebhrendi, ukuvavanya i-PDRN ke ngoko kuthetha ukujonga ngaphaya kwegama le-INCI ukuqonda inkqubo yemveliso, ulawulo lomgangatho kunye nemodeli yokubonelela ngasemva kwesithako.

I-Uniproma ibonelela ngamaxwebhu obuchwephesha, isikhokelo sokwenziwa, ulwazi olusemgangathweni kunye nenkxaso yokubonelela ngeenkonzo zorhwebo zophuhliso lwe-PDRN edibeneyo.